Lions have 64 points which is insurmountable as their nearest rivals Dynamos have 59 points with a single game to wind up the campaign. Hardknockers are third with 55 points in the 15-member league.
Gunners, who last season finished on third position, are second from the bottom with 28 points whereas new entrants Mantour are at the bottom with no point.
Defending champions Green Rangers have finished on eighth position.
Hungry Lions ace striker Austin Makobidi has won the Golden Boot Award after scoring 28 goals. His teammate Tinkhani Nyirenda is the second top goal scorer with 24 goals.
Player of the tournament is Thokozani Harrison from Mitundu FC.
Both Makobidi and Harrison will receive K10 000 (about $60). Central Region Youth Football Committee (CRYFC) chairperson Victor Longwe expressed optimism that the region will retain the honours.
â€œHungry Lions are playing some excellent football and it will be hard for other teams to beat them, I can assure you. There is so much talent in this league and we will once again retain the FMB title,â€ he said.
Longwe also praised attacking midfielder Harrison, saying he is destined for greater things.
â€œHe is just so natural and intelligent on the ball. No defender can stop him in the league,â€ said Longwe.
Leagues in the South and North are yet to be concluded.
In a related matter, the Under-17 Presidential Cup finals for Lilongwe district between Kilombero and Hardknockers will take pace on May 6, according to Longwe.