The bout is one of the three female contests lined up to curtain-raise an international fight between Osgood Kayuni and Tanzanian Allan Kamote.
Nkhwathi has only fought once. She faces Nyirenda who has nine wins, two draws and a loss.
Nyirenda said she would like to build her profile with wins.
Ã¢â‚¬Å“I do not want draws or losses to appear in my profile. That means another convincing win on Sunday.
Ã¢â‚¬Å“She is a destroyer, but that poses no danger to me. I am a silent killer,Ã¢â‚¬Â said Nkwanthi.
Nyirenda on the other hand, said she is set to end her opponentÃ¢â‚¬â„¢s boxing career.
Ã¢â‚¬Å“It is a pity that this is only her second bout and that I will knock her out for good. I wish she had fought more bouts before facing me. She has nothing to show against the destroyer. And I feel sorry that she has come all the way from Mzuzu to be embarrassed in Blantyre,Ã¢â‚¬Â she said.
In other females encounters Mchinji Boyz boxer Elizabeth Nota faces Chimwemwe Qaba whereas Bertha Hosea from Mchinji fights Martha Longwe of Nkhata Bay.
The bouts have been organised by Ngumi Boxing Stable whose owner Steven Msiska aims at promoting female boxing.
Ã¢â‚¬Å“We need more women in boxing and we are impressed that more are taking up the challenge,Ã¢â‚¬Â said Msiska.